New therapy may offer faster relief for cases of postpartum depression

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Postpartum depression may only affect a small portion of the population—about one in eight women, according to the Centers for Disease Control and Prevention—but for every single one of those new mothers, this condition could mean the difference between life and death. Existing treatments still leave many suffering, sometimes leading to tragic consequences.

D. Samba Reddy, a professor in the Department of Neuroscience and Experimental Therapeutics in the Texas A&M University College of Medicine, is the lead researcher of the lab that may have discovered a treatment for postpartum depression, which has historically gone largely undiagnosed and unaddressed.

Over the last two decades, Reddy has conducted extensive research to develop a new treatment method that makes use of the body’s natural chemistry to treat brain diseases. He coined this term “neurosteroid replacement therapy” to reflect the methodology of other, more-familiar types of replacement therapies, such as insulin replacement therapy or hormone replacement therapy. His most recent work applying this approach to postpartum depression was outlined in a recent paper published in the Journal of Neuroendocrinology.

Neurosteroids are steroids synthesized within the brain that have important regulatory effects on the brain’s function. One specific neurosteroid, allopregnanolone, is produced in increasing amounts during pregnancy. However, after childbirth, the neurosteroid levels drop, leading to chemical imbalances in the brain that can cause postpartum depression.

Reddy wondered, “Why don’t we replace the neurosteroids with the same neurosteroids that are naturally occurring in the brain—allopregnanolone?” This question would later lead to one of the most groundbreaking discoveries in women’s health: the formulation of allopregnanolone, in injection form, for treatment of postpartum depression. This medication, which was then renamed as brexanalone, was approved in 2019 as the first drug for postpartum depression.

Postpartum depression is unique in that there is a small window of time during which it can be treated; it varies from person to person, but the critical period is the first four weeks after the baby is born. The new mother’s body resumes the menstrual cycle after four to six weeks, and once the cycle starts, the body will start producing neurosteroids at normal levels again, and the new mother’s body is able to establish a rhythm.

Reddy emphasized a need for this treatment because “before neurosteroid replacement therapy, there was no medicine available that worked quickly enough to treat postpartum depression,” he said. “After childbirth, women don’t have weeks to wait on existing depression medications, which take at least three to four weeks before they take effect.”

Neurosteroids, on the other hand, work immediately as antidepressants because they have a rapid mechanism of action. They enhance an already-existing receptor in the brain, so when the drug is infused, the patient immediately starts feeling better, and after the recommended three-day duration of treatment, they’ll continue to feel better for weeks. This medication is to help new mothers replace their neurosteroids for the first few weeks after birth until their bodies restart production of these neurosteroids naturally.

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